Ontology highlight
ABSTRACT:
SUBMITTER: Callen E
PROVIDER: S-EPMC2709792 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Molecular cell 20090501 3
The DNA double-strand break (DSB) repair protein DNA-PKcs and the signal transducer ATM are both activated by DNA breaks and phosphorylate similar substrates in vitro, yet appear to have distinct functions in vivo. Here, we show that ATM and DNA-PKcs have overlapping functions in lymphocytes. Ablation of both kinase activities in cells undergoing immunoglobulin class switch recombination leads to a compound defect in switching and a synergistic increase in chromosomal fragmentation, DNA insertio ...[more]