Ontology highlight
ABSTRACT:
SUBMITTER: Chakrabarti O
PROVIDER: S-EPMC2709807 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Chakrabarti Oishee O Hegde Ramanujan S RS
Cell 20090601 6
The pathways leading from aberrant Prion protein (PrP) metabolism to neurodegeneration are poorly understood. Some familial PrP mutants generate increased (Ctm)PrP, a transmembrane isoform associated with disease. In other disease situations, a potentially toxic cytosolic form (termed cyPrP) might be produced. However, the mechanisms by which (Ctm)PrP or cyPrP cause selective neuronal dysfunction are unknown. Here, we show that both (Ctm)PrP and cyPrP can interact with and disrupt the function o ...[more]