Ontology highlight
ABSTRACT:
SUBMITTER: Kelly KA
PROVIDER: S-EPMC2709884 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Kelly Kimberly A KA Setlur Sunita R SR Ross Robert R Anbazhagan Rajesh R Waterman Peter P Rubin Mark A MA Weissleder Ralph R
Cancer research 20080401 7
Early detection and diagnosis of prostate cancer is key to designing effective treatment strategies. Microarrays have resulted in the discovery of hepsin (HPN) as a biomarker for detection of prostate cancer. In this study, we explore the development of HPN imaging probes for detection of prostate cancer. We used phage display to isolate HPN binding peptides with 190 + 2.2 nmol/L affinity in monomeric form and high specificity. The identified peptides were able to detect human prostate cancer on ...[more]