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Impaired long-term stability of CA1 place cell representation in mice lacking the transcription factor zif268/egr1.


ABSTRACT: Zif268 is a transcriptional regulator that plays a crucial role in maintenance of the late phases of hippocampal long-term potentiation (LTP) and consolidation of spatial memories. Because the hippocampal place cell system is essential for long-term spatial memory, we tested the hypothesis that zif268 is required for long-term stability of hippocampal place cell representations by recording CA1 place cells in mice lacking zif268. We found that zif268 gene deletion destabilized the representation of a familiar environment after exposure to a novel environment and impaired the long-term (24 h), but not short-term (1 h), stability of newly formed representations. These impairments could be rescued by repeated exposure to the novel environment, however. These results indicate that zif268 contributes to the long-term stability of spatial representations in CA1 and support the notion that the long-term stability of place cell representations requires transcription-dependent mechanisms similar to those observed in LTP.

SUBMITTER: Renaudineau S 

PROVIDER: S-EPMC2710630 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature

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Impaired long-term stability of CA1 place cell representation in mice lacking the transcription factor zif268/egr1.

Renaudineau Sophie S   Poucet Bruno B   Laroche Serge S   Davis Sabrina S   Save Etienne E  

Proceedings of the National Academy of Sciences of the United States of America 20090625 28


Zif268 is a transcriptional regulator that plays a crucial role in maintenance of the late phases of hippocampal long-term potentiation (LTP) and consolidation of spatial memories. Because the hippocampal place cell system is essential for long-term spatial memory, we tested the hypothesis that zif268 is required for long-term stability of hippocampal place cell representations by recording CA1 place cells in mice lacking zif268. We found that zif268 gene deletion destabilized the representation  ...[more]

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