Ontology highlight
ABSTRACT:
SUBMITTER: Letoffe S
PROVIDER: S-EPMC2710666 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Létoffé Sylvie S Heuck Gesine G Delepelaire Philippe P Lange Norbert N Wandersman Cécile C
Proceedings of the National Academy of Sciences of the United States of America 20090629 28
Because heme is a major iron-containing molecule in vertebrates, the ability to use heme-bound iron is a determining factor in successful infection by bacterial pathogens. Until today, all known enzymes performing iron extraction from heme did so through the rupture of the tetrapyrrol skeleton. Here, we identified 2 Escherichia coli paralogs, YfeX and EfeB, without any previously known physiological functions. YfeX and EfeB promote iron extraction from heme preserving the tetrapyrrol ring intact ...[more]