Ontology highlight
ABSTRACT:
SUBMITTER: Baker CL
PROVIDER: S-EPMC2711022 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Molecular cell 20090501 3
Circadian systems are comprised of multiple proteins functioning together to produce feedback loops driving robust, approximately 24 hr rhythms. In all circadian systems, proteins in these loops are regulated through myriad physically and temporally distinct posttranslational modifications (PTMs). To better understand how PTMs impact a circadian oscillator, we implemented a proteomics-based approach by combining purification of endogenous FREQUENCY (FRQ) and its interacting partners with quantit ...[more]