Ontology highlight
ABSTRACT:
SUBMITTER: Badie S
PROVIDER: S-EPMC2711581 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Badie Sophie S Liao Chunyan C Thanasoula Maria M Barber Paul P Hill Mark A MA Tarsounas Madalena M
The Journal of cell biology 20090501 4
The RAD51 paralogues act in the homologous recombination (HR) pathway of DNA repair. Human RAD51C (hRAD51C) participates in branch migration and Holliday junction resolution and thus is important for processing HR intermediates late in the DNA repair process. Evidence for early involvement of RAD51 during DNA repair also exists, but its function in this context is not understood. In this study, we demonstrate that RAD51C accumulates at DNA damage sites concomitantly with the RAD51 recombinase an ...[more]