Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC2712227 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Liu Yu Y Kuzuya Akinori A Sha Ruojie R Guillaume Johan J Wang Risheng R Canary James W JW Seeman Nadrian C NC
Journal of the American Chemical Society 20080729 33
We describe the synthesis of a hybrid DNA/organic macrocycle that is prepared by formation of an amide linkage across one full turn of DNA. Formation of a catenane proved that the linkage crossed a turn rather than running along the phosphodiester backbone contour. The product, a doubly tailed catenane, contains 5'- and 3'-termini that can be functionalized further or used to incorporate the catenane structure into other DNA assemblies. ...[more]