Ontology highlight
ABSTRACT:
SUBMITTER: Shen A
PROVIDER: S-EPMC2712671 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Structure (London, England : 1993) 20090501 5
The MogR transcriptional repressor of the intracellular pathogen Listeria monocytogenes recognizes AT-rich binding sites in promoters of flagellar genes to downregulate flagellar gene expression during infection. We describe here the 1.8 A resolution crystal structure of MogR bound to the recognition sequence 5' ATTTTTTAAAAAAAT 3' present within the flaA promoter region. Our structure shows that MogR binds as a dimer. Each half-site is recognized in the major groove by a helix-turn-helix motif a ...[more]