Ontology highlight
ABSTRACT:
SUBMITTER: Orr AG
PROVIDER: S-EPMC2712729 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Orr Anna G AG Orr Adam L AL Li Xiao-Jiang XJ Gross Robert E RE Traynelis Stephen F SF
Nature neuroscience 20090614 7
Cell motility drives many biological processes, including immune responses and embryonic development. In the brain, microglia are immune cells that survey and scavenge brain tissue using elaborate and motile cell processes. The motility of these processes is guided by the local release of chemoattractants. However, most microglial processes retract during prolonged brain injury or disease. This hallmark of brain inflammation remains unexplained. We identified a molecular pathway in mouse and hum ...[more]