Ontology highlight
ABSTRACT:
SUBMITTER: Beavis PA
PROVIDER: S-EPMC5330718 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Beavis Paul A PA Henderson Melissa A MA Giuffrida Lauren L Mills Jane K JK Sek Kevin K Cross Ryan S RS Davenport Alexander J AJ John Liza B LB Mardiana Sherly S Slaney Clare Y CY Johnstone Ricky W RW Trapani Joseph A JA Stagg John J Loi Sherene S Kats Lev L Gyorki David D Kershaw Michael H MH Darcy Phillip K PK
The Journal of clinical investigation 20170206 3
Chimeric antigen receptor (CAR) T cells have been highly successful in treating hematological malignancies, including acute and chronic lymphoblastic leukemia. However, treatment of solid tumors using CAR T cells has been largely unsuccessful to date, partly because of tumor-induced immunosuppressive mechanisms, including adenosine production. Previous studies have shown that adenosine generated by tumor cells potently inhibits endogenous antitumor T cell responses through activation of adenosin ...[more]