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Aziridines as intermediates in diversity-oriented syntheses of alkaloids.

ABSTRACT: The efficient synthesis of small molecules that collectively comprise optimal small-molecule screening collections is an important goal. With this in mind, we have used N-alkyl aziridines in a regio- and stereochemically controlled synthesis of polycyclic heterocycles based on nucleophilic ring opening and subsequent intramolecular cyclization.

SUBMITTER: Taylor AM

PROVIDER: S-EPMC2712733 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature

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Aziridines as intermediates in diversity-oriented syntheses of alkaloids.

Taylor Alexander M AM Schreiber Stuart L SL

Tetrahedron letters 20090701 26

The efficient synthesis of small molecules that collectively comprise optimal small-molecule screening collections is an important goal. With this in mind, we have used N-alkyl aziridines in a regio- and stereochemically controlled synthesis of polycyclic heterocycles based on nucleophilic ring opening and subsequent intramolecular cyclization. ...[more]

PMID: 20046991

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