Ontology highlight
ABSTRACT:
SUBMITTER: Pan G
PROVIDER: S-EPMC3448369 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
The Journal of organic chemistry 20120507 10
The total syntheses of the lycopodium alkaloids fawcettimine, fawcettidine, lycoflexine, and lycoposerramine B have been accomplished through an efficient, unified, and stereocontrolled strategy that relies on a Diels-Alder reaction to construct the cis-fused 6,5-carbocycles with one all-carbon quaternary center. Access to the enantioselective syntheses of both antipodes of those alkaloids can be achieved by kinetic resolution of the earliest intermediate via a Sharpless asymmetric dihydroxylati ...[more]