Ontology highlight
ABSTRACT:
SUBMITTER: Cole SE
PROVIDER: S-EPMC2712825 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Cole Sarah E SE LaRiviere Frederick J FJ Merrikh Christopher N CN Moore Melissa J MJ
Molecular cell 20090501 4
Eukaryotes possess numerous quality control systems that monitor both the synthesis of RNA and the integrity of the finished products. We previously demonstrated that Saccharomyces cerevisiae possesses a quality control mechanism, nonfunctional rRNA decay (NRD), capable of detecting and eliminating translationally defective rRNAs. Here we show that NRD can be divided into two mechanistically distinct pathways: one that eliminates rRNAs with deleterious mutations in the decoding site (18S NRD) an ...[more]