Ontology highlight
ABSTRACT:
SUBMITTER: Limoncelli KA
PROVIDER: S-EPMC5689013 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Limoncelli Kelly A KA Merrikh Christopher N CN Moore Melissa J MJ
RNA (New York, N.Y.) 20170927 12
In budding yeast, inactivating mutations within the 40S ribosomal subunit decoding center lead to 18S rRNA clearance by a quality control mechanism known as nonfunctional 18S rRNA decay (18S NRD). We previously showed that 18S NRD is functionally related to No-Go mRNA Decay (NGD), a pathway for clearing translation complexes stalled on aberrant mRNAs. Whereas the NGD factors Dom34p and Hbs1p contribute to 18S NRD, their genetic deletion (either singly or in combination) only partially stabilizes ...[more]