Ontology highlight
ABSTRACT:
SUBMITTER: Senften M
PROVIDER: S-EPMC2712835 | biostudies-literature | 2006 Feb
REPOSITORIES: biostudies-literature
Senften Mathias M Schwander Martin M Kazmierczak Piotr P Lillo Concepcion C Shin Jung-Bum JB Hasson Tama T Géléoc Gwenaëlle S G GS Gillespie Peter G PG Williams David D Holt Jeffrey R JR Müller Ulrich U
The Journal of neuroscience : the official journal of the Society for Neuroscience 20060201 7
Hair cells of the mammalian inner ear are the mechanoreceptors that convert sound-induced vibrations into electrical signals. The molecular mechanisms that regulate the development and function of the mechanically sensitive organelle of hair cells, the hair bundle, are poorly defined. We link here two gene products that have been associated with deafness and hair bundle defects, protocadherin 15 (PCDH15) and myosin VIIa (MYO7A), into a common pathway. We show that PCDH15 binds to MYO7A and that ...[more]