Ontology highlight
ABSTRACT:
SUBMITTER: Michel V
PROVIDER: S-EPMC7532178 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Michel Vincent V Pepermans Elise E Boutet de Monvel Jacques J England Patrick P Nouaille Sylvie S Aghaie Alain A Delhommel Florent F Wolff Nicolas N Perfettini Isabelle I Hardelin Jean-Pierre JP Petit Christine C Bahloul Amel A
Scientific reports 20201002 1
The hair bundle of cochlear hair cells is the site of auditory mechanoelectrical transduction. It is formed by three rows of stiff microvilli-like protrusions of graduated heights, the short, middle-sized, and tall stereocilia. In developing and mature sensory hair cells, stereocilia are connected to each other by various types of fibrous links. Two unconventional cadherins, protocadherin-15 (PCDH15) and cadherin-23 (CDH23), form the tip-links, whose tension gates the hair cell mechanoelectrical ...[more]