Ontology highlight
ABSTRACT:
SUBMITTER: Cheng J
PROVIDER: S-EPMC2712891 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Cheng Jun J Türkel Nezaket N Hemati Nahid N Fuller Margaret T MT Hunt Alan J AJ Yamashita Yukiko M YM
Nature 20081015 7222
Asymmetric division of adult stem cells generates one self-renewing stem cell and one differentiating cell, thereby maintaining tissue homeostasis. A decline in stem cell function has been proposed to contribute to tissue ageing, although the underlying mechanism is poorly understood. Here we show that changes in the stem cell orientation with respect to the niche during ageing contribute to the decline in spermatogenesis in the male germ line of Drosophila. Throughout the cell cycle, centrosome ...[more]