Ontology highlight
ABSTRACT:
SUBMITTER: Pirc Marolt T
PROVIDER: S-EPMC7588089 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Pirc Marolt Tinkara T Kramar Barbara B Bulc Rozman Klara K Šuput Dušan D Milisav Irina I
PloS one 20201026 10
Effects of aripiprazole on dopamine regulation are being tested as a treatment for patients with a dual diagnosis of schizophrenia and addictions, often cocaine dependence. Aripiprazole has one of the fewest side-effects among the second-generation antipsychotics. Nevertheless, severe aripiprazole hepatotoxicity was reported in persons with a history of cocaine and alcohol abuse. Here we report that therapeutically relevant aripiprazole concentrations, equal to laboratory alert levels in patient ...[more]