Ontology highlight
ABSTRACT:
SUBMITTER: Hlavacek WS
PROVIDER: S-EPMC27132 | biostudies-literature | 2000 Sep
REPOSITORIES: biostudies-literature
Hlavacek W S WS Stilianakis N I NI Notermans D W DW Danner S A SA Perelson A S AS
Proceedings of the National Academy of Sciences of the United States of America 20000901 20
Drug treatment of HIV type 1 (HIV-1) infection leads to a rapid initial decay of plasma virus followed by a slower second phase of decay. To investigate the role of HIV-1 retained on follicular dendritic cells (FDCs) in this process, we have developed and analyzed a mathematical model for HIV-1 dynamics in lymphoid tissue (LT) that includes FDCs. Analysis of clinical data using this model indicates that decay of HIV-1 during therapy may be influenced by release of FDC-associated virus. The bipha ...[more]