Ontology highlight
ABSTRACT:
SUBMITTER: Heesters BA
PROVIDER: S-EPMC4666623 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Heesters Balthasar A BA Lindqvist Madelene M Vagefi Parsia A PA Scully Eileen P EP Schildberg Frank A FA Altfeld Marcus M Walker Bruce D BD Kaufmann Daniel E DE Carroll Michael C MC
PLoS pathogens 20151201 12
Despite the success of antiretroviral therapy (ART), it does not cure Human Immunodeficiency Virus (HIV) and discontinuation results in viral rebound. Follicular dendritic cells (FDC) are in direct contact with CD4+ T cells and they retain intact antigen for prolonged periods. We found that human FDC isolated from patients on ART retain infectious HIV within a non-degradative cycling compartment and transmit infectious virus to uninfected CD4 T cells in vitro. Importantly, treatment of the HIV+ ...[more]