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Follicular Dendritic Cells Retain Infectious HIV in Cycling Endosomes.

ABSTRACT: Despite the success of antiretroviral therapy (ART), it does not cure Human Immunodeficiency Virus (HIV) and discontinuation results in viral rebound. Follicular dendritic cells (FDC) are in direct contact with CD4+ T cells and they retain intact antigen for prolonged periods. We found that human FDC isolated from patients on ART retain infectious HIV within a non-degradative cycling compartment and transmit infectious virus to uninfected CD4 T cells in vitro. Importantly, treatment of the HIV+ FDC with a soluble complement receptor 2 purges the FDC of HIV virions and prevents viral transmission in vitro. Our results provide an explanation for how FDC can retain infectious HIV for extended periods and suggest a therapeutic strategy to achieve cure in HIV-infected humans.

SUBMITTER: Heesters BA

PROVIDER: S-EPMC4666623 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Follicular Dendritic Cells Retain Infectious HIV in Cycling Endosomes.

Heesters Balthasar A BA Lindqvist Madelene M Vagefi Parsia A PA Scully Eileen P EP Schildberg Frank A FA Altfeld Marcus M Walker Bruce D BD Kaufmann Daniel E DE Carroll Michael C MC

PLoS pathogens 20151201 12

Despite the success of antiretroviral therapy (ART), it does not cure Human Immunodeficiency Virus (HIV) and discontinuation results in viral rebound. Follicular dendritic cells (FDC) are in direct contact with CD4+ T cells and they retain intact antigen for prolonged periods. We found that human FDC isolated from patients on ART retain infectious HIV within a non-degradative cycling compartment and transmit infectious virus to uninfected CD4 T cells in vitro. Importantly, treatment of the HIV+ ...[more]

PMID: 26623655

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