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Efficient synthesis of gamma-lactams by a tandem reductive amination/lactamization sequence.

ABSTRACT: A three-component method for the synthesis of highly substituted gamma-lactams from readily available maleimides, aldehydes, and amines is described. A new reductive amination/intramolecular lactamization sequence provides a straightforward route to the lactam products in a single manipulation. The general utility of this method is demonstrated by the parallel synthesis of a gamma-lactam library.

SUBMITTER: Noth J

PROVIDER: S-EPMC2713763 | biostudies-literature | 2008 May-Jun

REPOSITORIES: biostudies-literature

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Efficient synthesis of gamma-lactams by a tandem reductive amination/lactamization sequence.

Nöth Julica J Frankowski Kevin J KJ Neuenswander Benjamin B Aubé Jeffrey J Reiser Oliver O

Journal of combinatorial chemistry 20080314 3

A three-component method for the synthesis of highly substituted gamma-lactams from readily available maleimides, aldehydes, and amines is described. A new reductive amination/intramolecular lactamization sequence provides a straightforward route to the lactam products in a single manipulation. The general utility of this method is demonstrated by the parallel synthesis of a gamma-lactam library. ...[more]

PMID: 18338857

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