Ontology highlight
ABSTRACT:
SUBMITTER: Wickramaratne S
PROVIDER: S-EPMC3799944 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Wickramaratne Susith S Mukherjee Shivam S Villalta Peter W PW Schärer Orlando D OD Tretyakova Natalia Y NY
Bioconjugate chemistry 20130816 9
DNA-protein cross-links (DPCs) are ubiquitous, structurally diverse DNA lesions formed upon exposure to bis-electrophiles, transition metals, UV light, and reactive oxygen species. Because of their superbulky, helix distorting nature, DPCs interfere with DNA replication, transcription, and repair, potentially contributing to mutagenesis and carcinogenesis. However, the biological implications of DPC lesions have not been fully elucidated due to the difficulty in generating site-specific DNA subs ...[more]