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Efficient three-component Strecker reaction of aldehydes/ketones via NHC-amidate palladium(II) complex catalysis.
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ABSTRACT:
SUBMITTER: Jarusiewicz J
PROVIDER: S-EPMC2713785 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Publications
Efficient three-component Strecker reaction of aldehydes/ketones via NHC-amidate palladium(II) complex catalysis.
The Journal of organic chemistry 20090401 7
A simple and efficient one-pot, three-component method has been developed for the synthesis of alpha-aminonitriles. This Strecker reaction is applicable for aldehydes and ketones with aliphatic or aromatic amines and trimethylsilyl cyanide in the presence of a palladium Lewis acid catalyst in dichloromethane solvent at room temperature. ...[more]