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Palladium-catalyzed, pyrrolidine-mediated arylmethylation of ketones and aldehydes with coumarinyl(methyl) acetates.

ABSTRACT: We report the palladium-catalyzed, pyrrolidine-mediated ?-benzylation of enamines generated from aldehydes and ketones. The method allows for direct coupling of medicinally relevant coumarin moieties with aldehydes and ketones in good yield under mild conditions. The reaction is believed to proceed via a Pd-?-benzyl complex generated from (coumarinyl)methyl acetates.

SUBMITTER: Cattopadhyay K

PROVIDER: S-EPMC3443958 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature

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Palladium-catalyzed, pyrrolidine-mediated arylmethylation of ketones and aldehydes with coumarinyl(methyl) acetates.

Cattopadhyay Kalicharan K Recio Antonio A Tunge Jon A JA

Organic & biomolecular chemistry 20120725 34

We report the palladium-catalyzed, pyrrolidine-mediated α-benzylation of enamines generated from aldehydes and ketones. The method allows for direct coupling of medicinally relevant coumarin moieties with aldehydes and ketones in good yield under mild conditions. The reaction is believed to proceed via a Pd-π-benzyl complex generated from (coumarinyl)methyl acetates. ...[more]

PMID: 22832549

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