Mitochondrial dysfunction resulting from loss of cytochrome c impairs radiation-induced bystander effect.
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ABSTRACT: Cytochrome c is a pivotal protein that resides in mitochondria as component of mitochondria respiration and apoptosis initiator. Using murine cells lacking cytochrome c, we showed here that cytochrome c-deficient cells had attenuated reactive oxygen species/nitric oxide and micronuclei induction to radiation-induced bystander signals, indicating cytochrome c is essential for the bystander effect.
SUBMITTER: Yang G
PROVIDER: S-EPMC2714242 | biostudies-literature |
REPOSITORIES: biostudies-literature
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