Mitochondrial dysfunction resulting from loss of cytochrome c impairs radiation-induced bystander effect.
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ABSTRACT:
SUBMITTER: Yang G
PROVIDER: S-EPMC2714242 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
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Mitochondrial dysfunction resulting from loss of cytochrome c impairs radiation-induced bystander effect.
Yang G G Wu L L Chen S S Zhu L L Huang P P Tong L L Zhao Y Y Zhao G G Wang J J Mei T T Xu A A Wang Y Y
British journal of cancer 20090519 12
Cytochrome c is a pivotal protein that resides in mitochondria as component of mitochondria respiration and apoptosis initiator. Using murine cells lacking cytochrome c, we showed here that cytochrome c-deficient cells had attenuated reactive oxygen species/nitric oxide and micronuclei induction to radiation-induced bystander signals, indicating cytochrome c is essential for the bystander effect. ...[more]
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