Ontology highlight
ABSTRACT:
SUBMITTER: Lachmann HJ
PROVIDER: S-EPMC2715040 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Lachmann Helen J HJ Lowe Philip P Felix Sandra Daniela SD Rordorf Christiane C Leslie Kieron K Madhoo Sheril S Wittkowski Helmut H Bek Stephan S Hartmann Nicole N Bosset Sophie S Hawkins Philip N PN Jung Thomas T
The Journal of experimental medicine 20090413 5
The investigation of interleukin 1beta (IL-1beta) in human inflammatory diseases is hampered by the fact that it is virtually undetectable in human plasma. We demonstrate that by administering the anti-human IL-1beta antibody canakinumab (ACZ885) to humans, the resulting formation of IL-1beta-antibody complexes allowed the detection of in vivo-produced IL-1beta. A two-compartment mathematical model was generated that predicted a constitutive production rate of 6 ng/d IL-1beta in healthy subjects ...[more]