Ontology highlight
ABSTRACT:
SUBMITTER: Ballbach M
PROVIDER: S-EPMC6743338 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Ballbach Marlene M Hall Tobias T Brand Alina A Neri Davide D Singh Anurag A Schaefer Iris I Herrmann Eva E Hansmann Sandra S Handgretinger Rupert R Kuemmerle-Deschner Jasmin J Hartl Dominik D Rieber Nikolaus N
Journal of innate immunity 20160629 5
Cryopyrin-associated periodic syndromes (CAPS) are caused by mutations in the NLRP3 gene leading to overproduction of IL-1β and other NLRP3 inflammasome products. Myeloid-derived suppressor cells (MDSCs) represent a novel innate immune cell subset capable of suppressing T-cell responses. As inflammasome products were previously found to induce MDSCs, we hypothesized that NLRP3 inflammasome-dependent factors induce the generation of MDSCs in CAPS. We studied neutrophilic MDSCs, their clinical rel ...[more]