Ontology highlight
ABSTRACT:
SUBMITTER: Kayama Y
PROVIDER: S-EPMC2715088 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Kayama Yosuke Y Minamino Tohru T Toko Haruhiro H Sakamoto Masaya M Shimizu Ippei I Takahashi Hidehisa H Okada Sho S Tateno Kaoru K Moriya Junji J Yokoyama Masataka M Nojima Aika A Yoshimura Michihiro M Egashira Kensuke K Aburatani Hiroyuki H Komuro Issei I
The Journal of experimental medicine 20090622 7
To identify a novel target for the treatment of heart failure, we examined gene expression in the failing heart. Among the genes analyzed, Alox15 encoding the protein 12/15 lipoxygenase (LOX) was markedly up-regulated in heart failure. To determine whether increased expression of 12/15-LOX causes heart failure, we established transgenic mice that overexpressed 12/15-LOX in cardiomyocytes. Echocardiography showed that Alox15 transgenic mice developed systolic dysfunction. Cardiac fibrosis increas ...[more]