Genetic deletion of 12/15 lipoxygenase promotes effective resolution of inflammation following myocardial infarction.

ABSTRACT: 12/15 lipoxygenase (LOX) directs inflammation and lipid remodeling. However, the role of 12/15LOX in post-myocardial infarction (MI) left ventricular remodeling is unclear. To determine the role of 12/15LOX, 8-12 week-old C57BL/6 J wild-type (WT; n = 93) and 12/15LOX^-/- (n = 97) mice were subjected to permanent coronary artery ligation and monitored at day (d)1 and d5 post-operatively. Post-MI d28 survival was measured in male and female mice. No-MI surgery mice were maintained as d0 naïve controls. 12/15LOX^-/- mice exhibited higher survival rates with lower cardiac rupture and improved LV function as compared with WT post-MI. Compared to WT, neutrophils and macrophages in 12/15LOX^-/- mice were polarized towards N2 and M2 phenotypes, respectively, with incr

SUBMITTER: Kain V 

PROVIDER: S-EPMC5940552 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature