Netrin-1 acts as a survival factor for aggressive neuroblastoma.
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ABSTRACT:
SUBMITTER: Delloye-Bourgeois C
PROVIDER: S-EPMC2715117 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Publications
Netrin-1 acts as a survival factor for aggressive neuroblastoma.
Delloye-Bourgeois Céline C Fitamant Julien J Paradisi Andrea A Cappellen David D Douc-Rasy Setha S Raquin Marie-Anne MA Stupack Dwayne D Nakagawara Akira A Rousseau Raphaël R Combaret Valérie V Puisieux Alain A Valteau-Couanet Dominique D Bénard Jean J Bernet Agnès A Mehlen Patrick P
The Journal of experimental medicine 20090406 4
Neuroblastoma (NB), the most frequent solid tumor of early childhood, is diagnosed as a disseminated disease in >60% of cases, and several lines of evidence support the resistance to apoptosis as a prerequisite for NB progression. We show that autocrine production of netrin-1, a multifunctional laminin-related molecule, conveys a selective advantage in tumor growth and dissemination in aggressive NB, as it blocks the proapoptotic activity of the UNC5H netrin-1 dependence receptors. We show that ...[more]
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