Specific therapeutic schemes of omeprazole affect the orientation of Helicobacter pylori.
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ABSTRACT:
SUBMITTER: Azevedo-Vethacke M
PROVIDER: S-EPMC2715582 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Publications
Specific therapeutic schemes of omeprazole affect the orientation of Helicobacter pylori.
Azevedo-Vethacke Marina M Garten Désirée D Groll Claudia C Schreiber Sören S
Antimicrobial agents and chemotherapy 20090601 8
Until now, it has been unclear how proton pump inhibitors (PPIs) support Helicobacter pylori therapy. We tested whether the PPI omeprazole acts on the spatial orientation of H. pylori in the gastric mucus of infected Mongolian gerbils. Following repetitive PPI administration once daily but not following single doses or administration every 8 h, the bacterial spatial distribution changed, indicating a loss of orientation. Therefore, the therapeutic scheme of PPI administration may affect efficien ...[more]
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