Ontology highlight
ABSTRACT:
SUBMITTER: Verma D
PROVIDER: S-EPMC2715772 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Verma Dinesh D Ling Chen C Johannsen Eric E Nagaraja Tirumuru T Swaminathan Sankar S
Journal of virology 20090610 16
The Epstein-Barr virus (EBV) SM protein is essential for lytic EBV DNA replication and virion production. When EBV replication is induced in cells infected with an SM-deleted recombinant EBV, approximately 50% of EBV genes are expressed inefficiently. When EBV replication is rescued by transfection of SM, SM enhances expression of these genes by direct and indirect mechanisms. While expression of most EBV genes is either unaffected or enhanced by SM, expression of several genes is decreased in t ...[more]