Ontology highlight
ABSTRACT:
SUBMITTER: Kim DN
PROVIDER: S-EPMC3158499 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Kim Do Nyun DN Song Yoon Jae YJ Lee Suk Kyeong SK
Experimental & molecular medicine 20110701 7
Epstein-Barr virus (EBV) microRNAs (miRNAs) are expressed in EBV-associated tumors and cell lines, but the regulation mechanism of their expression is unclear yet. We investigated whether the expression of EBV miRNAs is epigenetically regulated in EBV-infected B cell lines. The expression of BART miRNAs was inversely related with the methylation level of the BART promoter at both steady-state and following 5-aza-2'-deoxycytidine treatment of the cells. The expression of BHRF1 miRNAs also became ...[more]