Truncation of TRIM5 in the Feliformia explains the absence of retroviral restriction in cells of the domestic cat.
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ABSTRACT:
SUBMITTER: McEwan WA
PROVIDER: S-EPMC2715776 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Publications
Truncation of TRIM5 in the Feliformia explains the absence of retroviral restriction in cells of the domestic cat.
McEwan William A WA Schaller Torsten T Ylinen Laura M LM Hosie Margaret J MJ Towers Greg J GJ Willett Brian J BJ
Journal of virology 20090603 16
TRIM5alpha mediates a potent retroviral restriction phenotype in diverse mammalian species. Here, we identify a TRIM5 transcript in cat cells with a truncated B30.2 capsid binding domain and ablated restrictive function which, remarkably, is conserved across the Feliformia. Cat TRIM5 displayed no restriction activity, but ectopic expression conferred a dominant negative effect against human TRIM5alpha. Our findings explain the absence of retroviral restriction in cat cells and suggest that disru ...[more]
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