Ontology highlight
ABSTRACT:
SUBMITTER: Ganser-Pornillos BK
PROVIDER: S-EPMC6858284 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Nature reviews. Microbiology 20190716 9
Mammalian cells express a variety of innate immune proteins - known as restriction factors - which defend against invading retroviruses such as HIV-1. Two members of the tripartite motif protein family - TRIM5α and TRIMCyp - were identified in 2004 as restriction factors that recognize and inactivate the capsid shell that surrounds and protects the incoming retroviral core. Research on these TRIM5 proteins has uncovered a novel mode of non-self recognition that protects against cross-species tra ...[more]