Ontology highlight
ABSTRACT:
SUBMITTER: Shen Y
PROVIDER: S-EPMC2716136 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Shen Yufeng Y Hixson Kim K KK Tolić Nikola N Camp David G DG Purvine Samuel O SO Moore Ronald J RJ Smith Richard D RD
Analytical chemistry 20080626 15
Protein proteolytic degradation is an essential component to proper cell function and its life cycle. Here, we study the protein degradation in yeast Saccharomyces cerevisiae cells on a proteome-wide scale by detection of the intermediate peptides produced from the intracellular degradation of proteins using sequencing-based tandem mass spectrometry. By tracing the detected approximately 1100 peptides and their approximately 200 protein-substrate origins we obtain evidence for new insights into ...[more]