Ontology highlight
ABSTRACT:
SUBMITTER: Curran K
PROVIDER: S-EPMC2716409 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Curran Kevin K Raible David W DW Lister James A JA
Developmental biology 20090613 2
We describe a mechanistic model whereby Foxd3, a forkhead transcription factor, prevents neural crest-derived precursors from acquiring a melanophore fate. Foxd3 regulates this fate choice by repressing the mitfa promoter in a subset of neural crest cells. mitfa is only expressed in a Foxd3-negative subset of neural crest cells, and foxd3 mutants show an increase in the spatial domain of mitfa expression, thereby suggesting that Foxd3 limits the mitfa domain. Furthermore, foxd3:gfp transgenic ze ...[more]