Ontology highlight
ABSTRACT:
SUBMITTER: Prakash H
PROVIDER: S-EPMC2716518 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Prakash Hridayesh H Becker Daniel D Böhme Linda L Albert Lori L Witzenrath Martin M Rosseau Simone S Meyer Thomas F TF Rudel Thomas T
PloS one 20090806 8
The resistance of epithelial cells infected with Chlamydophila pneumoniae for apoptosis has been attributed to the induced expression and increased stability of anti-apoptotic proteins called inhibitor of apoptosis proteins (IAPs). The significance of cellular inhibitor of apoptosis protein-1 (cIAP-1) in C. pneumoniae pulmonary infection and innate immune response was investigated in cIAP-1 knockout (KO) mice using a novel non-invasive intra-tracheal infection method. In contrast to wildtype, cI ...[more]