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The WAVE regulatory complex is inhibited.

ABSTRACT: The WAVE regulatory complex (WRC) transmits information from the Rac GTPase to the actin nucleator Arp2/3 complex. We have reconstituted recombinant human and Drosophila WRC in several forms and shown that they are inactive toward Arp2/3 complex but can be activated by Rac in a nucleotide-dependent fashion. Our observations identify core components needed for WAVE inhibition, reconcile contradictory existing mechanisms and reveal common regulatory principles for the WAVE/WASP family of proteins.

SUBMITTER: Ismail AM

PROVIDER: S-EPMC2716658 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature

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The WAVE regulatory complex is inhibited.

Ismail Ayman M AM Padrick Shae B SB Chen Baoyu B Umetani Junko J Rosen Michael K MK

Nature structural & molecular biology 20090412 5

The WAVE regulatory complex (WRC) transmits information from the Rac GTPase to the actin nucleator Arp2/3 complex. We have reconstituted recombinant human and Drosophila WRC in several forms and shown that they are inactive toward Arp2/3 complex but can be activated by Rac in a nucleotide-dependent fashion. Our observations identify core components needed for WAVE inhibition, reconcile contradictory existing mechanisms and reveal common regulatory principles for the WAVE/WASP family of proteins. ...[more]

PMID: 19363480

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