Dataset Information

Tracing the HIV-1 subtype B mobility in Europe: a phylogeographic approach.

ABSTRACT:

Background

The prevalence and the origin of HIV-1 subtype B, the most prevalent circulating clade among the long-term residents in Europe, have been studied extensively. However the spatial diffusion of the epidemic from the perspective of the virus has not previously been traced.

Results

In the current study we inferred the migration history of HIV-1 subtype B by way of a phylogeography of viral sequences sampled from 16 European countries and Israel. Migration events were inferred from viral phylogenies by character reconstruction using parsimony. With regard to the spatial dispersal of the HIV subtype B sequences across viral phylogenies, in most of the countries in Europe the epidemic was introduced by multiple sources and subsequently spread within local networks. Poland provides an exception where most of the infections were the result of a single point introduction. According to the significant migratory pathways, we show that there are considerable differences across Europe. Specifically, Greece, Portugal, Serbia and Spain, provide sources shedding HIV-1; Austria, Belgium and Luxembourg, on the other hand, are migratory targets, while for Denmark, Germany, Italy, Israel, Norway, the Netherlands, Sweden, Switzerland and the UK we inferred significant bidirectional migration. For Poland no significant migratory pathways were inferred.

Conclusion

Subtype B phylogeographies provide a new insight about the geographical distribution of viral lineages, as well as the significant pathways of virus dispersal across Europe, suggesting that intervention strategies should also address tourists, travellers and migrants.

SUBMITTER: Paraskevis D

PROVIDER: S-EPMC2717046 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature

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Publications

Tracing the HIV-1 subtype B mobility in Europe: a phylogeographic approach.

Paraskevis Dimitrios D Pybus Oliver O Magiorkinis Gkikas G Hatzakis Angelos A Wensing Annemarie Mj AM van de Vijver David A DA Albert Jan J Angarano Guiseppe G Asjö Birgitta B Balotta Claudia C Boeri Enzo E Camacho Ricardo R Chaix Marie-Laure ML Coughlan Suzie S Costagliola Dominique D De Luca Andrea A de Mendoza Carmen C Derdelinckx Inge I Grossman Zehava Z Hamouda Osama O Hoepelman Im I Horban Andrzej A Korn Klaus K Kücherer Claudia C Leitner Thomas T Loveday Clive C Macrae Eilidh E Maljkovic-Berry I I Meyer Laurence L Nielsen Claus C Op de Coul Eline Lm EL Ormaasen Vidar V Perrin Luc L Puchhammer-Stöckl Elisabeth E Ruiz Lidia L Salminen Mika O MO Schmit Jean-Claude JC Schuurman Rob R Soriano Vincent V Stanczak J J Stanojevic Maja M Struck Daniel D Van Laethem Kristel K Violin M M Yerly Sabine S Zazzi Maurizio M Boucher Charles A CA Vandamme Anne-Mieke AM

Retrovirology 20090520

<h4>Background</h4>The prevalence and the origin of HIV-1 subtype B, the most prevalent circulating clade among the long-term residents in Europe, have been studied extensively. However the spatial diffusion of the epidemic from the perspective of the virus has not previously been traced.<h4>Results</h4>In the current study we inferred the migration history of HIV-1 subtype B by way of a phylogeography of viral sequences sampled from 16 European countries and Israel. Migration events were inferr ...[more]

PMID: 19457244

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Dataset Information

Tracing the HIV-1 subtype B mobility in Europe: a phylogeographic approach.

Background

Results

Conclusion

Publications

Tracing the HIV-1 subtype B mobility in Europe: a phylogeographic approach.

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