Ontology highlight
ABSTRACT:
SUBMITTER: Brailoiu E
PROVIDER: S-EPMC2717647 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Brailoiu Eugen E Churamani Dev D Cai Xinjiang X Schrlau Michael G MG Brailoiu G Cristina GC Gao Xin X Hooper Robert R Boulware Michael J MJ Dun Nae J NJ Marchant Jonathan S JS Patel Sandip S
The Journal of cell biology 20090720 2
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a widespread and potent calcium-mobilizing messenger that is highly unusual in activating calcium channels located on acidic stores. However, the molecular identity of the target protein is unclear. In this study, we show that the previously uncharacterized human two-pore channels (TPC1 and TPC2) are endolysosomal proteins, that NAADP-mediated calcium signals are enhanced by overexpression of TPC1 and attenuated after knockdown of TPC1, an ...[more]