Ontology highlight
ABSTRACT:
SUBMITTER: Nishijo K
PROVIDER: S-EPMC2717773 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Nishijo Koichi K Hosoyama Tohru T Bjornson Christopher R R CR Schaffer Beverly S BS Prajapati Suresh I SI Bahadur Ali N AN Hansen Mark S MS Blandford Mary C MC McCleish Amanda T AT Rubin Brian P BP Epstein Jonathan A JA Rando Thomas A TA Capecchi Mario R MR Keller Charles C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20090330 8
Bioluminescent reporter genes are sensitive in situ tools for following disease progression in preclinical models, albeit they are subject to scattering and absorption in deep tissues. We have generated a bicistronic Cre/LoxP reporter mouse line that pairs the expression of firefly luciferase with quantifiable expression of a human placental alkaline phosphatase that is secreted into the serum (SeAP). With the use of this dual-modality bioreporter with a novel, inducible Pax7-CreER line for trac ...[more]