Ontology highlight
ABSTRACT:
SUBMITTER: Laufman O
PROVIDER: S-EPMC2718288 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Laufman Orly O Kedan Amir A Hong Wanjin W Lev Sima S
The EMBO journal 20090618 14
The crucial roles of Sec1/Munc18 (SM)-like proteins in membrane fusion have been evidenced in genetic and biochemical studies. SM proteins interact directly with SNAREs and contribute to SNARE pairing by a yet unclear mechanism. Here, we show that the SM protein, Sly1, interacts directly with the conserved oligomeric Golgi (COG) tethering complex. The Sly1-COG interaction is mediated by the Cog4 subunit, which also interacts with Syntaxin 5 through a different binding site. We provide evidence t ...[more]