Ontology highlight
ABSTRACT:
SUBMITTER: Markovic DS
PROVIDER: S-EPMC2718387 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Markovic D S DS Vinnakota K K Chirasani S S Synowitz M M Raguet H H Stock K K Sliwa M M Lehmann S S Kälin R R van Rooijen N N Holmbeck K K Heppner F L FL Kiwit J J Matyash V V Lehnardt S S Kaminska B B Glass R R Kettenmann H H
Proceedings of the National Academy of Sciences of the United States of America 20090715 30
Diffuse infiltration of glioma cells into normal brain tissue is considered to be a main reason for the unfavorable outcomes of patients with malignant gliomas. Invasion of glioma cells into the brain parenchyma is facilitated by metalloprotease-mediated degradation of the extracellular matrix. Metalloproteases are released as inactive pro-forms and get activated upon cleavage by membrane bound metalloproteases. Here, we show that membrane type 1 metalloprotease (MT1-MMP) is up-regulated in glio ...[more]