Dataset Information

Preinfection systemic inflammatory markers and risk of hospitalization due to pneumonia.

ABSTRACT:

Rationale

Elevated proinflammatory cytokines are associated with severity of pneumonia, but the role of preinfection cytokine levels in the predisposition to pneumonia in humans is less clear.

Objective

To ascertain role of preinfection inflammatory markers on susceptibility to community-acquired pneumonia (CAP).

Methods

Longitudinal analysis over 6.5 yr of a cohort that consisted of 70- to 79-yr-old well-functioning elderly individuals.

Measurements

Association between preinfection tumor necrosis factor (TNF), interleukin 6 (IL-6), and C-reactive protein (CRP) levels and CAP requiring hospitalization.

Results

Of the 3,075 participants, 161 (5.2%) developed at least one episode of CAP requiring hospitalization over a median duration of 3.3 yr. The highest tertiles of TNF (> 3.7 pg/ml) and IL-6 (> 2.4 pg/ml) were associated with increased risk of CAP, and the adjusted odds ratios were 1.6 (95% confidence interval [CI], 1.02-2.7) and 1.7 (95% CI, 1.1-2.8), respectively. The adjusted risk of CAP with at least one of these markers in the highest tertile was 1.6 (95% CI, 1.1-2.3). TNF and IL-6 levels in the highest tertile had a synergistic effect (p = 0.01 for interaction), and risk of CAP for both markers in the highest tertile was 2.8 (95% CI, 1.8-4.3). An FEV(1) of 50% or less of predicted was associated with the highest risk of CAP (adjusted odds ratio, 3.6; 95% CI, 2.3-5.6). Furthermore, TNF and IL-6 levels modified risk of CAP in participants with coexisting medical conditions and history of smoking.

Conclusion

In the well-functioning elderly subjects, preinfection systemic levels of TNF and IL-6 were associated with higher risk of CAP requiring hospitalization in smokers and those with coexisting medical conditions.

SUBMITTER: Yende S

PROVIDER: S-EPMC2718438 | biostudies-literature | 2005 Dec

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Preinfection systemic inflammatory markers and risk of hospitalization due to pneumonia.

Yende Sachin S Tuomanen Elaine I EI Wunderink Richard R Kanaya Alka A Newman Anne B AB Harris Tamara T de Rekeneire Nathalie N Kritchevsky Stephen B SB

American journal of respiratory and critical care medicine 20050915 11

<h4>Rationale</h4>Elevated proinflammatory cytokines are associated with severity of pneumonia, but the role of preinfection cytokine levels in the predisposition to pneumonia in humans is less clear.<h4>Objective</h4>To ascertain role of preinfection inflammatory markers on susceptibility to community-acquired pneumonia (CAP).<h4>Methods</h4>Longitudinal analysis over 6.5 yr of a cohort that consisted of 70- to 79-yr-old well-functioning elderly individuals.<h4>Measurements</h4>Association betw ...[more]

PMID: 16166617

Similar Datasets

Project description:ImportanceThe risk of cardiovascular disease (CVD) after infection is poorly understood.ObjectiveTo determine whether hospitalization for pneumonia is associated with an increased short-term and long-term risk of CVD.Design, settings, and participantsWe examined 2 community-based cohorts: the Cardiovascular Health Study (CHS, n = 5888; enrollment age, ≥65 years; enrollment period, 1989-1994) and the Atherosclerosis Risk in Communities study (ARIC, n = 15,792; enrollment age, 45-64 years; enrollment period, 1987-1989). Participants were followed up through December 31, 2010. We matched each participant hospitalized with pneumonia to 2 controls. Pneumonia cases and controls were followed for occurrence of CVD over 10 years after matching. We estimated hazard ratios (HRs) for CVD at different time intervals, adjusting for demographics, CVD risk factors, subclinical CVD, comorbidities, and functional status.ExposuresHospitalization for pneumonia.Main outcomes and measuresIncident CVD (myocardial infarction, stroke, and fatal coronary heart disease).ResultsOf 591 pneumonia cases in CHS, 206 had CVD events over 10 years after pneumonia hospitalization. CVD risk after pneumonia was highest in the first year. CVD occurred in 54 cases and 6 controls in the first 30 days (HR, 4.07; 95% CI, 2.86-5.27); 11 cases and 9 controls between 31 and 90 days (HR, 2.94; 95% CI, 2.18-3.70); and 22 cases and 55 controls between 91 days and 1 year (HR, 2.10; 95% CI, 1.59-2.60). Additional CVD risk remained elevated into the tenth year, when 4 cases and 12 controls developed CVD (HR, 1.86; 95% CI, 1.18-2.55). In ARIC, of 680 pneumonia cases, 112 had CVD over 10 years after hospitalization. CVD occurred in 4 cases and 3 controls in the first 30 days (HR, 2.38; 95% CI, 1.12-3.63); 4 cases and 0 controls between 31 and 90 days (HR, 2.40; 95% CI, 1.23-3.47); 11 cases and 8 controls between 91 days and 1 year (HR, 2.19; 95% CI, 1.20-3.19); and 8 cases and 7 controls during the second year (HR, 1.88; 95% CI, 1.10-2.66). After the second year, the HRs were no longer statistically significant.Conclusions and relevanceHospitalization for pneumonia was associated with increased short-term and long-term risk of CVD, suggesting that pneumonia may be a risk factor for CVD.

Dataset Information

Preinfection systemic inflammatory markers and risk of hospitalization due to pneumonia.

Rationale

Objective

Methods

Measurements

Results

Conclusion

Publications

Preinfection systemic inflammatory markers and risk of hospitalization due to pneumonia.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets