Unknown

Dataset Information

0

Angiotensins and Alzheimer's disease: a bench to bedside overview.

ABSTRACT: The pathology of Alzheimer's disease (AD) features amyloid beta peptide deposition, intracellular neurofibrillary tangles and deficits in the cholinergic pathway. Abnormal blood pressure is recognised as a risk factor for the development of AD, although the underlying mechanisms remain unproven. This review proposes angiotensins and associated enzymatic pathways as important mediators of recognised but undefined links between blood pressure and AD. Evidence in support of this involvement translates consistently from the most basic in vitro, in vivo and ex vivo experimental paradigms to more complex human-based observational and experimental studies, which also fortunately offer potential for therapeutic interventions against AD.

SUBMITTER: Kehoe PG 

PROVIDER: S-EPMC2719108 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Angiotensins and Alzheimer's disease: a bench to bedside overview.

Kehoe Patrick G PG  

Alzheimer's research & therapy 20090709 1

The pathology of Alzheimer's disease (AD) features amyloid beta peptide deposition, intracellular neurofibrillary tangles and deficits in the cholinergic pathway. Abnormal blood pressure is recognised as a risk factor for the development of AD, although the underlying mechanisms remain unproven. This review proposes angiotensins and associated enzymatic pathways as important mediators of recognised but undefined links between blood pressure and AD. Evidence in support of this involvement transla  ...[more]

Similar Datasets

Unknown Cerebrospinal Fluid Biomarkers in Alzheimer's Disease-From Brain Starch to Bench and Bedside.
| S-EPMC5617942 | biostudies-literature
Transcriptomics Molecular Diagnostics in Sepsis: from Bedside to Bench
2006-08-29 | GSE5663 | GEO
Unknown Research in Sickle Cell Disease: From Bedside to Bench to Bedside.
| S-EPMC8171370 | biostudies-literature
Unknown HSV-1 Oncolytic Viruses from Bench to Bedside: An Overview of Current Clinical Trials.
| S-EPMC7760226 | biostudies-literature
Unknown Platelets in chronic liver disease, from bench to bedside.
| S-EPMC7005648 | biostudies-literature
Unknown COVID-19 and Cardiovascular Disease: From Bench to Bedside.
| S-EPMC8048382 | biostudies-literature
Unknown Acute graft-versus-host disease: a bench-to-bedside update.
| S-EPMC4102709 | biostudies-literature
Unknown Development of new levodopa treatment strategies in Parkinson's disease-from bedside to bench to bedside.
| S-EPMC5441375 | biostudies-literature
Unknown Sonochemotherapy: from bench to bedside.
| S-EPMC4498442 | biostudies-other
Unknown Linagliptin: from bench to bedside.
| S-EPMC4018312 | biostudies-literature