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HSV-1 Oncolytic Viruses from Bench to Bedside: An Overview of Current Clinical Trials.

ABSTRACT: Herpes simplex virus 1 (HSV-1) provides a genetic chassis for several oncolytic viruses (OVs) currently in clinical trials. Oncolytic HSV1 (oHSV) have been engineered to reduce neurovirulence and enhance anti-tumor lytic activity and immunogenicity to make them attractive candidates in a range of oncology indications. Successful clinical data resulted in the FDA-approval of the oHSV talimogene laherparepvec (T-Vec) in 2015, and several other variants are currently undergoing clinical assessment and may expand the landscape of future oncologic therapy options. This review offers a detailed overview of the latest results from clinical trials as well as an outlook on newly developed HSV-1 oncolytic variants with improved tumor selectivity, replication, and immunostimulatory capacity and related clinical studies.

SUBMITTER: Koch MS

PROVIDER: S-EPMC7760226 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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HSV-1 Oncolytic Viruses from Bench to Bedside: An Overview of Current Clinical Trials.

Koch Marilin S MS Lawler Sean E SE Chiocca E Antonio EA

Cancers 20201126 12

Herpes simplex virus 1 (HSV-1) provides a genetic chassis for several oncolytic viruses (OVs) currently in clinical trials. Oncolytic HSV1 (oHSV) have been engineered to reduce neurovirulence and enhance anti-tumor lytic activity and immunogenicity to make them attractive candidates in a range of oncology indications. Successful clinical data resulted in the FDA-approval of the oHSV talimogene laherparepvec (T-Vec) in 2015, and several other variants are currently undergoing clinical assessment ...[more]

PMID: 33255871

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