Ontology highlight
ABSTRACT:
SUBMITTER: Hazra A
PROVIDER: S-EPMC2719293 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Cancer causes & control : CCC 20080514 9
We evaluated the association of a polymorphism in TCF7L2 (RS12255372) in the WNT signaling pathway, which previously has been strongly associated with risk of Type II Diabetes, with colorectal cancer (CRC) and adenoma in the prospective Nurses' Health Study (NHS) and Health Professionals Follow-up Study (HPFS) cohorts. Hyperinsulinemia may be related to the risk of colon adenoma and cancer, therefore this variant associated with reduced insulin secretion would be predicted to be inversely associ ...[more]