Ontology highlight
ABSTRACT:
SUBMITTER: Mitsiki E
PROVIDER: S-EPMC2719695 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Mitsiki Eirini E Papageorgiou Anastassios C AC Iyer Shalini S Thiyagarajan Nethaji N Prior Steven H SH Sleep Darrell D Finnis Chris C Acharya K Ravi KR
Biochemical and biophysical research communications 20090623 4
Thymidine phosphorylase (TP) first identified as platelet derived endothelial cell growth factor (PD-ECGF) plays a key role in nucleoside metabolism. Human TP (hTP) is implicated in angiogenesis and is overexpressed in several solid tumors. Here, we report the crystal structures of recombinant hTP and its complex with a substrate 5-iodouracil (5IUR) at 3.0 and 2.5A, respectively. In addition, we provide information on the role of specific residues in the enzymatic activity of hTP through mutagen ...[more]